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Oct

9

Abstract

From Here :

There are six particle types that are consistently recovered from the skin surface of those suffering from Morgellons disease;

1) ribbon-like fibers
2) rounded fibers
3) capsule-like particles
4) black flakes/grains
5) worm-like particles
6) stellate-shaped (“starfish-shaped”) particles.

The fibers are often pigmented and may luminesce under ultraviolet light. These six particle types were recovered from a hot water tank that was suspected of harboring contaminants causing chronic skin irritation and other debilitating symptoms to the scalp, neck and shoulders of the homeowner. The hot water tank had been idle for more than 2 years and is thought to have been contaminated by soil/groundwater organisms. Replacement of the hot water system and water pipes eliminated these contaminants and resulted in a marked improvement in the homeowner’s health. Microscopic examination and microbial analysis of water samples collected before hot tank removal show the presence of numerous fiber-producing microorganisms.

Tentative identification is based on morphological characteristics and include the following primary organisms of interest:

1) gliding bacteria, cyanobacteria or blue-green
algae, and rhizosphere bacteria (slime-producing bacteria),
2) actinomyces (spore-forming
filamentous bacteria),
3) plasmodial slime molds, oomycete water molds, chytrids and algae
(protists),
4) zygomycetes and ascomycetes (fungi/yeast).

Of particular interest is the keratin degrading aquatic fungi or chytrids. Evidence for their presence in hot water tank samples is indicated by the occurrence of capsule-like Morgellons particles that have been identified as parasitized pine pollen grains. Chytrid populations are obligate parasites of frogs, nematodes, algae, cyanobacteria, and plants. Based on the findings of this Phase I study it is proposed that prolonged dermal exposure to algae-rich conditions may promote the incidental growth of opportunistic keratin degrading populations causing chronic symptoms associated with Morgellons disease. These findings serve as a focus for further understanding the ecological significance of the organisms identified in this study and the role they may play as causative agents for this disease. Membrane filters, culture slants, and water samples have been archived for further study.

Here are the links to the illustrations and tables referenced in the study :

Illustrations and Images

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Tables

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Oct

9

From Here :
Abstract
Introduction: This review of 25 consecutive patients with Morgellons disease (MD) was undertaken for two primary and extremely fundamental reasons. For semantic accuracy, there is only one “proven” MD patient: the child first given that label.
The remainder of inclusive individuals adopted the label based on related descriptions from 1544 through 1884, an internet description quoted from Sir Thomas Browne (1674), or was given the label by practitioners using similar sources. Until now, there has been no formal characterization of MD from detailed examination of all body systems. Our second purpose was to differentiate MD from Delusions of Parasitosis (DP), another “informal” label that fit most of our MD patients. How we defined and how we treated these patients depended literally on factual data that would determine outcome. How they were labeled in one sense was irrelevant, except for the confusing conflict rampant in the medical community, possibly significantly skewing treatment outcomes.

Case presentation: Clinical information was collected from 25 of 30 consecutive self-defined patients with Morgellons disease consisting of laboratory data, medical history and physical examination findings. Abnormalities were quantified and grouped by system, then compared and summarized, but the numbers were too small for more complex mathematical analysis. The quantification of physical and laboratory abnormalities allowed at least the creation of a practicalclinical boundary, separating probable Morgellons from non-Morgellons patients. All the 25 patients studied meet the most commonly used DP definitions.

Conclusions: These data suggest Morgellons disease can be characterized as a physical human illness with an often related delusional component in adults. All medical histories support that behavioral aberrancies onset only after physical symptoms. The identified abnormalities include both immune deficiency and chronic inflammatory markers that correlate strongly with immune cytokine excess.

The review of 251 current NLM DP references leads us to the possibility that Morgellons disease andDP are grossly truncated labels of the same illness but with the reversal of the cause-effect order.Further, the patients’ data suggest that both illnesses have an infectious origin.

Oct

8

From Here :

Abstract

Morgellons disease is an emerging multisystem illness characterized by unexplained dermopathy and unusual skinassociated
filament production. Despite evidence demonstrating that an infectious process is involved and that lesions are not self-inflicted, many medical practitioners continue to claim that this illness is delusional.

We present relevant clinical observations combined with chemical and light microscopic studies of material collected from three patients with Morgellons disease. Our study demonstrates that Morgellons disease is not delusional and that skin lesions with unusual fibers are not self-inflicted or psychogenic. We provide chemical, light microscopic and immunohistological evidence that filaments associated with this condition originate from human epithelial cells, supporting the hypothesis that the fibers are composed of keratin and are products of keratinocytes.

Oct

8

Etiology of Yan (Morgellons) Disease: A New Plant-Like Infectious Organism from Brazil and Its Skin Manifestations

Chun-Yeung Yan
Tsui Wah ouse, Upper Wong Tai Sin state, Kowloon, Hong Kong, SA .
Corresponding author email: yan.disease@yahoo.com

From Here :

Abstract:
This paper describes the etiological organism causing a new human infection, ie, Yan (also known as Morgellons) disease.
Colored threads, black speck-like material, and granules are formed within and/or on the skin surface.

The organism has four main morphological forms, ie, tube-shaped fibers, amorphous tuber masses, fibrous roots, and seeds. Brilliant red and blue autofluorescent pigments similar to phycobiliproteins have been observed. The seed form of the organism grows in solid potato and blood agar as pointed masses, and in potato broth as interconnecting bundles of fibers.

The seed form of the organism was grown in a hamster/mouse model as light brownish tuber masses interconnecting with fibrous roots. The main symptoms for the patient are of biting, stinging, and a “shooting” sensation from the skin caused by the sharp and pointed ends of the seed form of the organism.

Oct

4

From Here :

Abstract

Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coinfecting microorganisms have been implicated in the pathogenesis of this veterinary illness. Morgellons disease is an emerging human dermopathy characterized by the presence of filamentous fibers of undetermined composition, both in lesions and subdermally. While the etiology of Morgellons disease is unknown, there is serological and clinical evidence linking this phenomenon to Lyme borreliosis and coinfecting tick-borne agents. Although the microscopy of Morgellons filaments has been described in the medical literature, the structure and pathogenesis of these fibers is poorly understood. In contrast, most microscopy of digital dermatitis has focused on associated pathogens and histology rather than the morphology of late-stage filamentous fibers. Clinical, laboratory, and microscopic characteristics of these two diseases are compared.


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